Let be an agglomeration function for the pollutant effects
on individuals residing at . If the cytodynamic model is
used, this effect quantification measures the overall effect of the
pollutant under consideration on one individual only. From the viewpoint
of a health care decision maker, it is therefore important to incorporate
the pollutant effect on the whole population. Fortunately, this poses no
problem. Suppose that we have given a
population density function ,
for all . The objective function to be minimized
is then given by

Obviously, to evaluate *f* we do not only need to evaluate
at several points, but we also need a numerical integration routine.
Since in the present version of *OLAF* the pollutant concentration
and the health effect function is computed on a fixed Cartesian grid of
size with grid points , the
integral in (5.2) can be replaced by the weighted
sum over all grid points considered, where the weights are 1/*NM*.

Wed Dec 22 12:25:31 CET 1999