We are interested in the study and selective modulation of medically relevant protein networks. Our aim is to combat diseases such as cancer and HIV on a genetic level with molecules that selectively disrupt protein-protein interactions that are vital for the disease state. Through our collaborative efforts with several groups here at the University of Southampton, and around the world, we are developing compounds that tackle diseases in a novel way.

We are also interested in the field of Synthetic Biology. There are several projects currently underway in our labs, aiming to reprogram cellular behaviour through introduction of non-native genes and reconfiguration of protein networks. We are also active in developing new approaches to de novo construction of synthetic genomes and non-natural molecules that behave analogously to their counterparts in living systems.

To explore further, click on the Cancer, Pathogens, Synthetic Biology or Protein Networks links above.

We thank the following for funding our research: